Abstract #2580

Studying the effect of medication status on resting state network metrics in Parkinson’s disease

Saadnah Naidu^1,2, Yue Lily Xing^1,2, and Dorothee Auer^2,3

¹Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

Current drug therapies for Parkinson’s disease (PD) offer symptom control without the capability for disease modification. Furthermore, unpredictable on/off fluctuations and dyskinesias present challenges in titrating appropriate doses. Our study aims to utilise resting state functional MRI (fMRI) to determine the effect of PD medication, as preliminary step to future work to address these limitations.

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