Abstract #2587

Free-Water Imaging Improves the Evaluation of White and Gray-Matter in Early Parkinson’s Disease

Christina Andica¹, Koji Kamagata¹, Taku Hatano², Yuki Takenaka^1,3, Asami Saito¹, Mana Kuramochi^1,3, Wataru Uchida^1,3, Akifumi Hagiwara^1,4, Takashi Ogawa², Haruka Takeshige-Amano², Masaaki Hori¹, Nobutaka Hattori², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Radiological Sciences, Tokyo Metropolitan University, Graduate School of Human Health Sciences, Tokyo, Japan, ⁴Department of Radiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan

We applied bi-tensor diffusion model to evaluate the microstructural changes of white (WM) and gray matter (GM) in patients with early Parkinson’s disease (PDs). Our results demonstrated that the bi-tensor diffusion model could be used to disentangle neuroinflammation and axonal degeneration in early PDs with more precise estimations of localized microstructural changes compared to the single-tensor model. Our findings also suggest that microstructural changes in early PD may be preceded by neuroinflammation and followed by axonal degeneration, with WM changes preceding GM changes. Finally, the bi-tensor model also enabled to show possible compensatory mechanisms in PD occurring in the cerebellum.

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