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Abstract #2587

Free-Water Imaging Improves the Evaluation of White and Gray-Matter in Early Parkinson’s Disease

Christina Andica1, Koji Kamagata1, Taku Hatano2, Yuki Takenaka1,3, Asami Saito1, Mana Kuramochi1,3, Wataru Uchida1,3, Akifumi Hagiwara1,4, Takashi Ogawa2, Haruka Takeshige-Amano2, Masaaki Hori1, Nobutaka Hattori2, and Shigeki Aoki1

1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Radiological Sciences, Tokyo Metropolitan University, Graduate School of Human Health Sciences, Tokyo, Japan, 4Department of Radiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan

We applied bi-tensor diffusion model to evaluate the microstructural changes of white (WM) and gray matter (GM) in patients with early Parkinson’s disease (PDs). Our results demonstrated that the bi-tensor diffusion model could be used to disentangle neuroinflammation and axonal degeneration in early PDs with more precise estimations of localized microstructural changes compared to the single-tensor model. Our findings also suggest that microstructural changes in early PD may be preceded by neuroinflammation and followed by axonal degeneration, with WM changes preceding GM changes. Finally, the bi-tensor model also enabled to show possible compensatory mechanisms in PD occurring in the cerebellum.

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