Abstract #2589

Atlas based Diffusion Abnormalities in Substantia Nigra in Parkinson's Disease

Apoorva Safai¹, Shweta Prasad^2,3, Jitender Saini⁴, Pramod Pal², and Madhura Ingalhalikar¹

¹Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, ²Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, India, ³3Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Pune, India, ⁴4Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India

Parkinson’s disease (PD) is characterized by neuronal loss of dopaminergic neurons in the substantia nigra (SN). This study aims to gain deeper insights into the abnormalities in SN by evaluating the diffusion metrics of the SN in a large cohort of patients with PD. To precisely delineate the SN, neuromelanin sensitive MRI images were obtained from a set of healthy controls and were used to create a probabilistic atlas of the SN. Using this atlas, we observed significantly higher radial and mean diffusivity of bilateral SN in patients with PD suggesting microstructural abnormalities that could potentially serve as bio-markers for PD.

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