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Abstract #2589

Atlas based Diffusion Abnormalities in Substantia Nigra in Parkinson's Disease

Apoorva Safai1, Shweta Prasad2,3, Jitender Saini4, Pramod Pal2, and Madhura Ingalhalikar1

1Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, 2Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, India, 33Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Pune, India, 44Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India

Parkinson’s disease (PD) is characterized by neuronal loss of dopaminergic neurons in the substantia nigra (SN). This study aims to gain deeper insights into the abnormalities in SN by evaluating the diffusion metrics of the SN in a large cohort of patients with PD. To precisely delineate the SN, neuromelanin sensitive MRI images were obtained from a set of healthy controls and were used to create a probabilistic atlas of the SN. Using this atlas, we observed significantly higher radial and mean diffusivity of bilateral SN in patients with PD suggesting microstructural abnormalities that could potentially serve as bio-markers for PD.

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