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Abstract #2591

Analysis of Structural Connectivity using Certain Nuclei as Seeds in Patients with Parkinson’s Disease

Haining Wei1, Zhangxuan Hu1, Yuhui Xiong1, Le He1, Yan Tong2, Yu Ma3, Hua Guo1, and Xuesong Li1,4

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Neuromodulation Center, Tsinghua University YuQuan Hospital, Beijing, China, 4School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China

In this study, we aim to evaluate the relationships between fiber connectivity starting from specific nucleus regions to the whole brain and the Unified Parkinson’s Disease Rating Scale (UPDRS)-III scores in patients with Parkinson's disease. The results showed that the structural connectivity to the whole brain starting from bilateral internal global pallidus and caudate nucleus has significant negative correlations with the UPDRS-III scores. In the contrary, no significant correlations was found for the network starting from the putamen and external global pallidus. The strong negative correlation implies that these specific nuclei may play significant roles in the severity of Parkinson's disease. This finding is of great importance for further clinical research.

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