Abstract #2598

Altered Claustral Functional Connectivity in Parkinson’s Disease Patients with Mild Cognitive Impairment.

Karthik Sreenivasan¹, Ece Bayram¹, Sarah Banks², Jason Longhurst¹, Xiaowei Zhuang¹, Zhengshi Yang¹, Dietmar Cordes¹, Aaron Ritter¹, Jessica Caldwell¹, Brent Bluett³, and Virendra Mishra¹

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²University of California, San Diego, San Diego, CA, United States, ³Stanford University, Stanford, CA, United States

Studies have shown α-synuclein pathology in the claustrum of Parkinson’s disease (PD) patients and its correlation with the onset of cognitive dysfunction in PD. In this study we use resting state fMRI to examine claustral functional connectivity network changes in PD patients with mild cognitive impairment. Our results show increased claustral-cortical connectivity in the PD-MCI group, which may indicate additional effort is required in the PD-MCI group to maintain network integration. The increased load of claustrum is somewhat mitigated by medication in PD patients with cognitive impairment.

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