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Abstract #2603

Structural MRI abnormalities and the immune system are correlated with neuroinflammation in Neuropsychiatric Systemic Lupus Erythematosus: a retrospective study on a large and well-defined patient cohort.

Francesca Inglese1, Ilse Kant2, Ece Ercan3, Mark van Buchem1, Margreet Steup-Beekman4, Tom Huizinga4, Cesar Magro-Checa4, Itamar Ronen1, and Jeroen de Bresser1

1Department of Radiology, LUMC, Leiden, Netherlands, 2Department of Radiology, UMCU, Utrecht, Netherlands, 3Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 4Department of Rheumatology, LUMC, Leiden, Netherlands

Neuropsychiatric Systemic Lupus Erythematosus (NP-SLE) is associated with cerebral abnormalities, but their relation to the inflammatory and ischemic clinical phenotypes is unknown. We performed a retrospective structural brain study within a large, clinically well-defined patient cohort of NP-SLE patients (inflammatory and ischemic) and non-NP-SLE patients. Patients with inflammatory, but not ischemic, NP-SLE showed lower grey matter and white matter volumes, and higher White Matter Hyperintensity volumes compared to non-NP-SLE patients. Brain abnormalities were also associated with the complement system. In conclusion, only inflammatory NP-SLE showed more severe structural brain abnormalities, and these were associated with a specific complement component.

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