Memory and executive dysfunctions burden HIV patients even in the highly active antiretroviral treatment (HAART) era. The neurobiological correlates of these cognitive symptoms remain unclear limiting development of targeted treatment options. Functional magnetic resonance imaging (fMRI) is a promising route to estimate neural signature of HIV-related neurocognitive decline. We examined brain activity in HIV+/HAART+ vs. healthy individuals during execution of semantic memory task. Results show that famous names induce lower activation in left caudate, right thalamus and left middle occipital gyrus in HIV+ vs. healthy group, despite lack of behavioral differences. Such hypoactivation suggests brain functional reorganization in HIV+/HAART+ patients.