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Abstract #2636

Visualization of the Substantia Nigra Pars Compacta: comparison between DANTE T1-SPACE and T1-SPACE

Sonoko Oshima1, Yasutaka Fushimi1, Tomohisa Okada2, Akira Yamamoto3, Satoshi Nakajima1, Gosuke Okubo1, Hikaru Fukutomi1, Yusuke Yokota1, John Grinstead4, Sinyeob Ahn5, and Kaori Togashi1

1Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Integrated Clinical Education Center, Kyoto University Hospital, Kyoto, Japan, Kyoto, Japan, 4Siemens Healthineers, Portland, OR, United States, 5Siemens Healthineers, San Francisco, CA, United States

Neuromelanin-sensitive magnetic resonance techniques have been used for depicting neuromelanin-rich structures such as the substantia nigra pars compacta (SNpc). We compared visualization of the SNpc between delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE) and T1-SPACE without DANTE pulse (T1-SPACE) in 8 healthy volunteers. DANTE T1-SPACE provided better delineation of the SNpc and showed higher contrast than T1-SPACE. DANTE T1-SPACE may be a viable tool for evaluating the SNpc.

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