Abstract #2636

Visualization of the Substantia Nigra Pars Compacta: comparison between DANTE T1-SPACE and T1-SPACE

Sonoko Oshima¹, Yasutaka Fushimi¹, Tomohisa Okada², Akira Yamamoto³, Satoshi Nakajima¹, Gosuke Okubo¹, Hikaru Fukutomi¹, Yusuke Yokota¹, John Grinstead⁴, Sinyeob Ahn⁵, and Kaori Togashi¹

¹Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Integrated Clinical Education Center, Kyoto University Hospital, Kyoto, Japan, Kyoto, Japan, ⁴Siemens Healthineers, Portland, OR, United States, ⁵Siemens Healthineers, San Francisco, CA, United States

Neuromelanin-sensitive magnetic resonance techniques have been used for depicting neuromelanin-rich structures such as the substantia nigra pars compacta (SNpc). We compared visualization of the SNpc between delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE) and T1-SPACE without DANTE pulse (T1-SPACE) in 8 healthy volunteers. DANTE T1-SPACE provided better delineation of the SNpc and showed higher contrast than T1-SPACE. DANTE T1-SPACE may be a viable tool for evaluating the SNpc.

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