Abstract #2638

Visualizing and Characterizing the Habenula with Magnetic Resonance Imaging

Naying He¹, Sean Kumar Sethi², Chencheng Zhang³, Yan Li¹, Yongsheng Chen⁴, Bomin Sun³, Fuhua Yan¹, and Ewart Mark Haacke²

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, shanghai, China, ²Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, ³Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Radiology, Wayne State University, Detroit, MI, United States

The habenulae are a small pair of nuclei which serve as a hub between the limbic forebrain and midbrain monoameric neurons. It is a target for the treatment of major depressive disorder using deep brain stimulation, which requires precise pre-treatment mapping. We visualized and characterized the habenula using multiple MRI contrasts and maps to quantify its properties and delineate the structure between lateral and medial side. Axially, we observed elevated iron in the posterior aspect, which we believe to be the lateral habenula. Quantitatively, we also noted similarities of the lateral habenula specifically to white matter.

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