Abstract #2650

Functional and Microstructural Changes in the Brain After Carotid Endarterectomy

Marc D Lindley¹, Adam Bernstein¹, Andrew McKinnon², Chidi Ugonna¹, Denise Bruck³, Kevin Johnson³, Maria Altbach³, Lee Ryan², Gloria Guzman³, Nan-kuei Chen¹, Ying-hui Chou², Theodore Trouard¹, and Craig Weinkauf⁴

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ²Psychology, University of Arizona, Tucson, AZ, United States, ³Medical Imaging, University of Arizona, Tucson, AZ, United States, ⁴Vascular Surgery, University of Arizona, Tucson, AZ, United States

Carotid endarterectomy (CEA) for clinically asymptomatic patients has been shown effective in reducing stroke risk. The impact that CEA has on functional connectivity or microstructure in the brain has not been studied. 14 clinically asymptomatic underwent resting state fMRI (rs-fMRI), diffusion MRI (dMRI), and neurocognitive testing pre-operatively and 4-6 months post-operatively. Functional correlation analysis on rs-fMRI was performed by analyzing the average within network correlations. Apparent fiber density calculations were performed to assess the microstructural changes before and after surgery. RS-fMRI and dMRI analysis showed changes before and after CEA.

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