Carotid endarterectomy (CEA) for clinically asymptomatic patients has been shown effective in reducing stroke risk. The impact that CEA has on functional connectivity or microstructure in the brain has not been studied. 14 clinically asymptomatic underwent resting state fMRI (rs-fMRI), diffusion MRI (dMRI), and neurocognitive testing pre-operatively and 4-6 months post-operatively. Functional correlation analysis on rs-fMRI was performed by analyzing the average within network correlations. Apparent fiber density calculations were performed to assess the microstructural changes before and after surgery. RS-fMRI and dMRI analysis showed changes before and after CEA.