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Abstract #2666

Measure Cerebral Microstructure Alterations in SVD and BVD Using Diffusion Kurtosis Imaging and Investigate the Correlation with Cognitive Impairment

Wenjing Lan1, Shuang Xu1, Yang Liu1, Kaiyu Wang2, and Lizhi Xie2

1The First Hospital of Jilin University, Changchun, China, 2GE Healthcare, China, Beijing, China

Diffusion tensor imaging (DTI) is one of the most popular diffusion MRI methods in the study of ageing. Diffusion kurtosis imaging, which is a recent novel extension of DTI to provide additional metrics quantifying non-Gaussianity of water diffusion in brain tissues, was applied throughout the study. We investigated diffusional alternations arising from brain small vessel disease, and compared results with age and educational level-matched big vessel disease and healthy controls. We also investigated the correlation between these diseases and cognitive impairment.

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