Diffusion tensor imaging (DTI) is one of the most popular diffusion MRI methods in the study of ageing. Diffusion kurtosis imaging, which is a recent novel extension of DTI to provide additional metrics quantifying non-Gaussianity of water diffusion in brain tissues, was applied throughout the study. We investigated diffusional alternations arising from brain small vessel disease, and compared results with age and educational level-matched big vessel disease and healthy controls. We also investigated the correlation between these diseases and cognitive impairment.
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