Abstract #2670

Changes to Blood-Brain Barrier Water Permeability After CPAP Treatment in Patients with Obstructive Sleep Apnea

Xiang He¹, Kenneth Wengler², Karl Spuhler², Muhammed Amin³, and Chuan Huang¹

¹Radiology, Stony Brook University, Stony Brook, NY, United States, ²Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ³Medicine, Stony Brook University, Stony Brook, NY, United States

In patients with obstructive sleep apnea (OSA), intermittent ischemia and re-oxygenation leads to disruption of blood-brain barrier (BBB) integrity. In this study changes in BBB water permeability parameters, water extraction fraction (E_w) and water permeability surface area product (PS_w), in patients with OSA before and after 8-weeks of continuous positive airway pressure (CPAP) treatment were investigated using the recently developed Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS) technique. Compared to healthy controls, OSA patients exhibited lower CBF, PS_w and E_w before CPAP. After 8-weeks of CPAP, patients showed increased CBF, PSw and Ew demonstrating the improvement of BBB integrity.

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