Abstract #2705

ExploreASL: a collaborative effort to process and explore multi-center ASL data

Henk Jan Mutsaerts¹, Jan Petr², Paul Groot¹, Silvia Ingala¹, Andrew Robertson³, Lena Vaclavu¹, Inge Groote⁴, Hugo Kuijf⁵, Owen O'Daly⁶, Fernando Zelaya⁶, Pieter Vandemaele⁷, Alle Meije Wink¹, Ilse Kant⁵, Matthan Caan¹, Catherine Morgan⁸, Jeroen de Bresser⁵, Elisabeth Lysvik⁴, Anouk Schrantee¹, Zahra Shirzadi⁹, Joost Kuijer¹, Udunna Anazodo¹⁰, Edo Richard¹, Reinoud Bokkers¹¹, Liesbeth Reneman¹, Mario Masellis⁹, Eric Achten⁷, Matthias Günther¹², Bradley MacIntosh⁹, Xavier Golay¹³, Jeroen Hendrikse⁵, Michael Chapell¹⁴, Matthias van Osch¹⁵, David Thomas¹³, Enrico De Vita¹⁶, Atle Bjornerud⁴, Aart Nederveen¹, Iris Asllani¹⁷, and Frederik Barkhof¹

¹Amsterdam University Medical Center, Amsterdam, Netherlands, ²Helmholtz-Zentrum Dresden-Rossendorf, Institute for Radiopharmaceutical Cancer Research, Dresden, Germany, ³Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, ON, Canada, ⁴University of Oslo, Oslo, Norway, ⁵University Medical Center Utrecht, Utrecht, Netherlands, ⁶Institute of Psychology, Kings College London, London, United Kingdom, ⁷Ghent University Hospital, Ghent, Belgium, ⁸University of Auckland, Auckland, New Zealand, ⁹Sunnybrook Research Institute, Toronto, ON, Canada, ¹⁰Lawson Health Research Institute, London, ON, Canada, ¹¹University Medical Center Groningen, Groningen, Netherlands, ¹²Mevis Fraunhofer, Bremen, Germany, ¹³University College London, London, United Kingdom, ¹⁴Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ¹⁵Leiden University Medical Center, Leiden, Netherlands, ¹⁶Kings College London, London, United Kingdom, ¹⁷Rochester Institute of Technology, Rochester, NY, United States

Arterial spin labeling (ASL) has undergone significant development since its inception; yet, standardized images processing procedures remain elusive. We present ExploreASL, a robust open source ASL image processing pipeline for clinical studies. Initiated through the European COST action ASL network, this joint effort provides integration and analysis of both single- and multi-center datasets across different operating systems. ExploreASL is optimized for both native- and standard-space analyses, and provides visual and automatic quality control on all intermediate and final images, allowing exploration of ASL datasets from multiple perspectives.

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