Abstract #2713

Toblerone: partial volume estimation on the cortical ribbon

Thomas Kirk^1,2, Timothy Coalson³, Flora Kennedy McConnell^1,2, and Michael Chappell^1,2

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Department of Neuroscience, Washington University School of Medicine, St Louis, MO, United States

Toblerone is a new method for estimating partial volumes on the cortical ribbon using surfaces as input (eg those produced by FreeSurfer). Evaluation has been performed using both simulations and subjects drawn from the Human Connectome Project. The estimates returned differ from those produced by existing tools such as FSL's FAST, which will have implications for the analysis of functional imaging data (notably ASL). A preliminary analysis of an ASL dataset has been performed using Toblerone's PV estimates.

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