Objectives: Our aim was to distinguish PWMLs and focal hemorrhage lesions using quantitative measures. Materials and Methods: In the current study, we acquired multi-echo gradient echo MRI data in neonates with hypoxic ischemic encephalopathy, and post-processed them as R2* relaxation maps and quantitative susceptibility maps (QSM). Manually drawing regions of interest (ROIs) on R2* maps, we measured R2* and susceptibility values of the lesions. Results: We found that R2* and susceptibility values are significantly increased in focal hemorrhage lesions, compared to PWMLs. Conclusions: R2* and QSM can be used to help clinicians distinguish and measure these lesions.