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Abstract #2719

Quantitative Analysis of Punctate White Matter Lesions Using Quantitative Susceptibility Mapping and R2* Relaxation

Yuting Zhang1, Alexander Rauscher2, and Alexander Mark Weber2

1Children’s Hospital of Chongqing Medical University, Chongqing, China, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada

Objectives: Our aim was to distinguish PWMLs and focal hemorrhage lesions using quantitative measures. Materials and Methods: In the current study, we acquired multi-echo gradient echo MRI data in neonates with hypoxic ischemic encephalopathy, and post-processed them as R2* relaxation maps and quantitative susceptibility maps (QSM). Manually drawing regions of interest (ROIs) on R2* maps, we measured R2* and susceptibility values of the lesions. Results: We found that R2* and susceptibility values are significantly increased in focal hemorrhage lesions, compared to PWMLs. Conclusions: R2* and QSM can be used to help clinicians distinguish and measure these lesions.

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