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Abstract #2721

Comparison of Gradient Echo and Gradient Echo Sampling of Spin Echo Sequence for the Quantification of the Oxygen Extraction Fraction by Combining Quantitative Susceptibility Mapping and Blood Oxygenation Level Dependency

Simon Hubertus1, Sebastian Thomas1, Junghun Cho2, Shun Zhang3,4, Yi Wang2,3, and Lothar R. Schad1

1Computer Assisted Clincial Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States, 3Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 4Department of Radiology, Tongji Hospital, Wuhan, China

The oxygen extraction fraction (OEF) is a promising biomarker for cerebral tissue vitality. Combining quantitative blood oxygenation level-dependent (qBOLD) modelling and quantitative susceptibility mapping (QSM) from gradient echo (GRE) data revealed promising results but still suffered from biases in white matter and required good parameter initialization. We showed that using an additional gradient echo sampling of spin echo (GESSE) sequence enables OEF reconstruction with higher accuracy, precision and robustness to parameter initialization in simulation. Yet, this increased robustness did still not allow for parameter initialization without prior knowledge of local distributions in vivo, which lead to a non-physiological gray-white matter contrast in the OEF.

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