Abstract #2727

Intrinsic vulnerability of low blood flow watershed to white matter hyperintensities in cerebral small vessel disease

Chunwei Ying¹, Andria L. Ford², Peter Kang², Alla Al-Habib², Slim Fellah², Yasheng Chen², Jin-Moo Lee^1,2, and Hongyu An¹

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States

White matter hyperintensities (WMH), a major neuroradiological feature of cerebral small vessel disease (CSVD), have a characteristic spatial distribution in the deep white matter and periventricular regions. In this study, we demonstrated a striking spatial overlap between WMH lesion hot spots and the watershed region, defined by a nadir in CBF within the white matter, suggesting that watershed is a region with intrinsic vulnerability to CSVD-related injury.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.