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Abstract #2730

Using Vascular Territories to Predict Disconnection Profiles in Post-Stroke Aphasia

Natalie Busby1, Ajay D Halai1,2, Ying Zhao3, Geoff J.M. Parker4,5, and Matt Lambon Ralph1,2

1Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, United Kingdom, 2MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 3Department of Psychology, University of Cambridge, Cambridge, United Kingdom, 4Quantitative Biomedical Imaging Laboratory, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 5Bioxydyn Ltd., Rutherford House, Manchester, Manchester, United Kingdom

Damage sustained to the brain post-stroke appears random but it may be constrained by the underlying neurovasculature; brain regions supplied by the occluded arterial branch will be affected. Combinations of vascular territories were matched to lesions from 62 post-stroke patients. Anatomical connectivity mapping, a measure of whole-brain connectivity, was used to estimate disconnection in each patient through summing disconnection associated with the territories which best matched their lesion. This novel methodology demonstrated that disconnection following a left-hemispheric stroke can be explained by the underlying neurovasculature and may be of particular interest when no diffusion data is available in the patient.

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