Damage sustained to the brain post-stroke appears random but it may be constrained by the underlying neurovasculature; brain regions supplied by the occluded arterial branch will be affected. Combinations of vascular territories were matched to lesions from 62 post-stroke patients. Anatomical connectivity mapping, a measure of whole-brain connectivity, was used to estimate disconnection in each patient through summing disconnection associated with the territories which best matched their lesion. This novel methodology demonstrated that disconnection following a left-hemispheric stroke can be explained by the underlying neurovasculature and may be of particular interest when no diffusion data is available in the patient.
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