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Abstract #2740

Negative BOLD cerebrovascular reactivity in stroke patients: a sign of misery perfusion of the affected hemisphere

Marco Piccirelli1, Christiaan Hendrik Bas van Niftrik1, Giovanni Muscas1, Martina Sebök1, Lita von Bieberstein1, Susanne Wegener1, Oliver Bozinov1, Giuseppe Esposito1, Andreas Luft1, Luca Regli1, Christoph Stippich1, and Jorn Fierstra1

1University Hospital Zurich, Zurich, Switzerland

Subjects with hemodynamic failure stage 2 (i.e. misery-perfusion) have heightened risk of acute and chronic brain tissue damage. One of the most important signs of misery-perfusion is a negative cerebrovascular reactivity (CVR). CVR is defined as a blood flow response to a vasoactive stimulus. Recently blood-oxygenation-level-dependent (BOLD) CVR was proposed to detect misery-perfusion. However, BOLD-CVR MRI signal does not reflect CBF changes directly and discrepancies between negative BOLD-CVR and negative CBF changes have been reported. To better assess these discrepancies, we performed a multimodal clinical misery-perfusion assessment with perfusion-weighted-MRI and transcranial-Doppler complimentary to BOLD-CVR in patients with symptomatic steno-occlusive disease.

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