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Abstract #2768

Common gray matter atrophy in individuals with different behavioral addictions: a voxel-wise meta-analysis

Kun Qin1, Feifei Zhang1, and Qiyong Gong1,2

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychology, School of Public Administration, Sichuan University, Chengdu, China

In order to figure out the common structural alterations in behavioral addicts among various publications and to find a biomarker for future improvement of diagnostic category, we searched for voxel based morphometry studies compared between patients and healthy controls and pooled them together in a meta-analytic way by using AES-SDM. 22 studies comprising 5 different addictive behaviors were included. 576 patients showed GM reduction in the left ACC, right striatum and right SMA compared with 635 HCs. In summary, our findings revealed common GM decreases in frontostriatal circuitry, consistent with previous multimodal neuroimaging findings in addiction.

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