Abstract #2770

Regional Cortical Thickness Changes and Neurocognitive Performance in Perinatally HIV-infected Youth

Manoj Kumar Sarma¹, Margaret A. Keller², Paul M. Macey³, Tamara Welikson⁴, David E. Michalik⁵, Karin Nielsen-Saines ⁶, Jaime Deville ⁶, Joseph A. Church⁷, Eva Operskalski ⁸, Andrea Kovacs ⁸, Irwin Walot⁹, Joseph Ventura¹⁰, and M. Albert Thomas¹

¹Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States, ³School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁴Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁵Infectious Disease-Pediatrics, Miller Children’s Hospital of Long Beach, Long Beach, CA, United States, ⁶Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁷Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁸Pediatrics, Keck School of Medicine at University of Southern California, Los Angeles, CA, United States, ⁹Radiology, Harbor-UCLA Medical Center, Los Angeles, CA, United States, ¹⁰Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Despite effective viral suppression, youth with perinatal HIV (PHIVY) often demonstrate long-term cognitive deficits. We measured grey matter cortical thickness as a measure of brain structural integrity in 11 PHIVY receiving long term cART compared to 16 age-matched controls and assessed neurocognitive performance. The PHIVY group performed significantly worse than controls. Regions of significantly thinner and thicker cortex in PHIVY were observed which may contribute to these deficits in neurocognitive function. Cortical thickness in PHIVY was correlated with current CD4 count and neurocognitive performance. Our findings suggest the potential importance of continued monitoring of PHIVY.

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