Abstract #2776

Differential Relationship of GABA and GLX in Dorsal vs. Ventral Prefrontal Cortex and Their Relationship To Age and Gender

Mark S Brown¹, Harry R Smolker², Rebecca J Helmuth², and Marie T Banich²

¹Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ²Institute of Cognitive Science, Dept of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States

MRS was employed in two regionally distinct prefrontal voxels (dorsal and ventral) in 62 adult females and 119 adolescents (60 males, 59 females) to determine the variations of GABA and GLX concentrations with regional specificity, participant gender, and age. The results indicate that levels of prefrontal neurotransmitter concentrations are influenced by age. Furthermore, the results suggest that the relationship between neurotransmitter levels can vary for adjacent portions of cortex, being more highly correlated for the dorsal than ventral voxel.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.