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Abstract #2776

Differential Relationship of GABA and GLX in Dorsal vs. Ventral Prefrontal Cortex and Their Relationship To Age and Gender

Mark S Brown1, Harry R Smolker2, Rebecca J Helmuth2, and Marie T Banich2

1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Institute of Cognitive Science, Dept of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States

MRS was employed in two regionally distinct prefrontal voxels (dorsal and ventral) in 62 adult females and 119 adolescents (60 males, 59 females) to determine the variations of GABA and GLX concentrations with regional specificity, participant gender, and age. The results indicate that levels of prefrontal neurotransmitter concentrations are influenced by age. Furthermore, the results suggest that the relationship between neurotransmitter levels can vary for adjacent portions of cortex, being more highly correlated for the dorsal than ventral voxel.

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