Heterogeneity of motor phenotypes is a clinically well-recognized fundamental aspect of amyotrophic lateral sclerosis (ALS).The body region of onset is one of independent primary attributes of ALS motor phenotype heterogeneity. In order to investigate the patterns of brain atrophy between ALS patients with bulbar and limb onset and analyse its correlation with clinical characteristics , cortical thickness analyses were performed. ALS Patients with limb onset revealed the majority of significant cortical thinning in the limb segment of the motor cortex, and patients with bulbar onset, in the bulbar segments. The findings suggest that neuroimaging could be a helpful objective measure to estimate of upper motor neuron loss.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords