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Abstract #2778

Different Cortical Thinning Pattern in Primary Motor Cortex Correspond to Clinical Characteristics of Amyotrophic Lateral Sclerosis Subtypes

Haining Li1, Qiuli Zhang1, Qianqian Duan1, Jingmei Xie2, and Ming Zhang1

1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, 2Department of Medical Imaging of the Second Hospital of Yulin, Yuling, China

Heterogeneity of motor phenotypes is a clinically well-recognized fundamental aspect of amyotrophic lateral sclerosis (ALS).The body region of onset is one of independent primary attributes of ALS motor phenotype heterogeneity. In order to investigate the patterns of brain atrophy between ALS patients with bulbar and limb onset and analyse its correlation with clinical characteristics , cortical thickness analyses were performed. ALS Patients with limb onset revealed the majority of significant cortical thinning in the limb segment of the motor cortex, and patients with bulbar onset, in the bulbar segments. The findings suggest that neuroimaging could be a helpful objective measure to estimate of upper motor neuron loss.

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