Meeting Banner
Abstract #2793

Disrupted topological brain organizations in large-scale cortical networks between impaired and nonimpaired active fighters

Virendra R Mishra1, Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Sarah Banks2, Dietmar Cordes1, and Charles Bernick3

1Imaging Research, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of California, San Diego, San Diego, CA, United States, 3Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

Using neuropsychological scores from the Professional Fighters Brain Health Study (PFBHS), this study first identified 70 cognitively impaired active professional fighters, and then matched 70 nonimpaired fighters but matched on demographics, and other fighting criteria. This study shows that repeated head trauma is associated with altered coordination of large-scale structural brain networks, especially in the long-range connections. Furthermore, the cortical thickness of regions identified as hubs has the potential of developing into a predictive biomarker for identifying the fighters that will develop cognitive decline due to repeated head trauma.

This abstract and the presentation materials are available to members only; a login is required.

Join Here