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Abstract #2802

Multi-modal 7T imaging of the Locus Coeruleus in healthy older adults

Catarina Rua1, Claire O'Callaghan2, Luca Passamonti3, P Simon Jones3, Kamen Tsvetanov4, James Rowe3,5, Rong Ye3,5, Adrian Carpenter1, Christopher T Rodgers1, and Guy Williams1

1Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 2Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, United Kingdom, 3Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 4Department of Psychology, Centre for Speech, Language and the Brain, University of Cambridge, Cambridge, United Kingdom, 5Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom

The Locus Coeruleus (LC) is the main source of cerebral noradrenaline, which modulates many cognitive domains from attention and motivation to mood and memory. However, the LC is a small structure located in the mid-brain, proven difficult to detect in-vivo. We studied healthy individuals using high-resolution MT-w, R2*, QSM, and fMRI at 7T to characterize the LC’s shape and size, magneto-chemical and functional properties. While no R2* or QSM contrast was found in the LC, it was clearly detected in MT-images and showed widespread functional connectivity towards cortex and cerebellum, These results are the benchmark for future studies in dementia.

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