Abstract #2865

Amide proton transfer in high grade glioma: Correlation with apparent diffusion coefficient, relative cerebral blood volume and pharmacokinetic imaging parameters

Masanori Nakajo¹, Kiyohisa Kamimura¹, Tomohide Yoneyama¹, Yoshihiko Fukukura¹, Takashi Iwanaga², Yuta Akamine³, Jochen Keupp⁴, and Takashi Yoshiura¹

¹Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Kagoshima University Hospital, Kagoshima, Japan, ³Philips Japan, Tokyo, Japan, ⁴Philips Research, Hamburg, Germany

Our purpose was to investigate potential correlations amide proton transfer signal intensity (APTSI) with apparent diffusion coefficient, relative cerebral blood volume and pharmacokinetic imaging parameters in high grade glioma (HGG). APTSI showed significant positive correlations with ADC (ρ = 0.582, p < 0.001) and with Ve (ρ = 0.300, p = 0.002), and a significant negative correlation with Kep (ρ = -0.337, p = 0.002). These results suggested that high APTSI in HGG may reflect proteins and peptides in large extracellular space, in addition to those in the intracellular space.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.