Peripheral neuropathy in diabetes is a common and poorly understood disease; previous methods to evaluate nerve-associated microvascular angiopathy are contrast-based and exclude patients with severe nephropathies or allergies to contrast agents. We adapt a combined a flow-sensitive alternating inversion recovery (FAIR)-sequence with a single-voxel readout such as Point RESolved Spectroscopy (PRESS) to measure peripheral nerve perfusion in healthy subjects and diabetes patients. Our preliminary results suggest that diabetes patients have a lower nerve/muscle perfusion ratio than non-diabetic subjects.
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