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Abstract #2896

Measurement of peripheral nerve perfusion using FAIR PRESS

Ke Zhang1,2, Johann M.E. Jende2, Volker J. Sturm2, Lukas R. Buschle1, Artur Hahn2, Sabine Heiland2, Heinz-Peter Schlemmer1, Martin Bendszus2, Christian H. Ziener1, and Felix T. Kurz2

1Department of Radiology, German Cancer Research Center, Heidelberg, Germany, 2Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany

Peripheral neuropathy in diabetes is a common and poorly understood disease; previous methods to evaluate nerve-associated microvascular angiopathy are contrast-based and exclude patients with severe nephropathies or allergies to contrast agents. We adapt a combined a flow-sensitive alternating inversion recovery (FAIR)-sequence with a single-voxel readout such as Point RESolved Spectroscopy (PRESS) to measure peripheral nerve perfusion in healthy subjects and diabetes patients. Our preliminary results suggest that diabetes patients have a lower nerve/muscle perfusion ratio than non-diabetic subjects.

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