Abstract #2911

Crossover intraindividual comparison of ionic and non-ionic macrocyclic gadollinium based contrast media in orthotopic glioblastoma model: Pathologic correlation of dynamic contrast enhancement characteristics at 9.4T MRI

Chi-Hoon Choi¹, Kyung Sik Yi¹, Janggeun Cho², Chulhyun Lee³, and Sang-Hoon Cha^1,2

¹Radiology, Chungbuk University Hospital, Cheongju-si, Korea, Republic of, ²Radiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju-si, Korea, Republic of, ³Division of Magnetic Resonance Research, Korea Basic Science Institute, Cheongju-si, Korea, Republic of

The DCE parameters including K^trans and V_e have been used to assess glioblastoma treatment responses reflecting tumor cellularity and tumor vasculature. We hypothesized that the enhancement pattern of the ionic macrocyclic contrast agent used in glioblastoma DCE study, which interacts with the negative charge on the surface of the tumor cell, was different from that of the nonionic one. We demonstrated it with prospective DCE experiments using the orthotopic glioblastoma models as well as K^trans and V_e from ionic were more correlated with tumor pathology than nonionic. These findings may aid clinical choice of GBCA in DCE-MRI study.

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