Abstract #2915

Volume of anisotropic diffusion abnormality as prognostic imaging marker in treated glioblastoma patients

Bart Roelf Jan van Dijken¹, Chao Li^2,3, Peter Jan van Laar¹, Shuo Wang^4,5, Stephen J Price², and Anouk van der Hoorn^1,2

¹Radiology, Medical Imaging Center (MIC), University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Brain Tumour Imaging Group, Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s hospital, University of Cambridge, Cambridge, United Kingdom, Cambridge, United Kingdom, ³Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China, Shanghai, China, ⁴Department of Radiology, University of Cambridge, Cambridge, UK, Cambridge, United Kingdom, ⁵The Centre for Mathematical Imaging in Healthcare, Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, United Kingdom

The purpose of this study was to investigate the prognostic value of anisotropic diffusion abnormality in 30 treated glioblastoma patients. Diffusion tensor imaging was performed after chemoradiotherapy and volumes of diffusion abnormalities were extracted. Our results showed that a larger volume of high anisotropic abnormality was associated with worsened patient survival. Anisotropic diffusion can therefore potentially be employed as a prognostic imaging marker in longitudinal management of glioblastoma patients.

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