This study addresses concerns over the degree to which the relationship between the cerebral BOLD MRI signal and a CO2 flow stimulus is non-linear. The issue was tested using a quantitative BOLD stimulus in a large population of healthy controls. The results indicate that linear modelling of the response compared to the sigmoid model underestimated the response by ≈ 10%. This would indicate that linear modelling of the BOLD is a reasonable surrogate for flow measurement in subjects undergoing cerebrovascular reactivity testing.
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