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Abstract #2936

Skin blood flow functions as a potential proxy for cerebral blood flow in adults with sickle cell disease

Brijesh Kumar Yadav1,2, Nicolas Currier3, Gersham Dent3, Paul S Swerdlow4, Indryas Woldie4, Muhammad Shahid4, Sean K Sethi5, Wenting Wang3, Kiarash Ghassaban5, Willem Birkhoff6, Jacobus Burggraaf6, Jaspert de Vries6, Jaladhar Neelavalli2, William E. Hobbs7, E Mark Haacke1,2, and Ajay Verma8

1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 2Department of Radiology, Wayne State University, Detroit, MI, United States, 3Biogen Inc., Cambridge, MA, United States, 4Department of Hematology-Oncology, Wayne State University, Detroit, MI, United States, 5MR Innovations, Detroit, MI, United States, 6Centre for Human Drug Research, Leiden, Netherlands, 7Bioverativ, a Sanofi company, Waltham, MA, United States, 8United Neuroscience, Hauppauge, NY, United States

Even though the prevalence of stroke in adults with sickle cell disease (SCD) is higher compared to children, no accepted screening measures are available for identifying adults with SCD at high risk for strokes. Despite cerebral blood flow (CBF) from transcranial Doppler being an established surrogate measure of stroke risk in children, it is not feasible in adults and MRI is uneconomical and inefficient for screening. We examined skin blood flow using laser speckle contrast imaging as a peripheral surrogate of CBF using MRI. Skin blood flow was highly correlated with CBF in sickle cell patients with excellent test-retest reliability.

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