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Abstract #2973

Clinically viable g-ratio imaging with unified readout at 3T: evaluation and comparison

Francesco Grussu1,2, Marco Battiston1, Ferran Prados1,3,4, Torben Schneider5, Enrico Kaden2, Rebecca S. Samson1, Daniel C. Alexander2, and Claudia A. M. Gandini Wheeler-Kingshott1,6,7

1Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 4Universitat Oberta de Catalunya, Barcelona, Spain, 5Philips UK, Guildford, Surrey, United Kingdom, 6Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 7Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy

The current way of performing g-ratio imaging is via multi-modal MRI with mixed readouts. This approach can limit the geometrical correspondence of multi-modal maps required for g- ratio calculation. Here we compare g-ratio imaging performed with innovative unified spin echo EPI readout to standard mixed-readout measurements (spoiled gradient echo and spin echo EPI). A unified readout is a feasible alternative to mixed readouts: both provide biologically plausible metrics, with comparable scan-rescan repeatability. Additionally, a unified EPI readout is compatible with multiband acceleration, and enables joint multi-contrast modelling. Our work paves the way for richer multi-contrast acquisitions that could improve g-ratio imaging.

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