The current way of performing g-ratio imaging is via multi-modal MRI with mixed readouts. This approach can limit the geometrical correspondence of multi-modal maps required for g- ratio calculation. Here we compare g-ratio imaging performed with innovative unified spin echo EPI readout to standard mixed-readout measurements (spoiled gradient echo and spin echo EPI). A unified readout is a feasible alternative to mixed readouts: both provide biologically plausible metrics, with comparable scan-rescan repeatability. Additionally, a unified EPI readout is compatible with multiband acceleration, and enables joint multi-contrast modelling. Our work paves the way for richer multi-contrast acquisitions that could improve g-ratio imaging.
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