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Abstract #2975

Simultaneous Multi-Slice Spin and Gradient Echo Dynamic Susceptibility-Contrast Perfusion Imaging of Gliomas

Misung Han1, Baolian Yang2, Brice Fernandez3, Marisa Lafontaine1, Brian Burns4, Suchandrima Banerjee4, and Janine M Lupo1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Applications and Workflow, GE Healthcare, Waukesha, WI, United States, 3Applications and Workflow, GE Healthcare, Orsay, France, 4Applications and Workflow, GE Healthcare, Menlo Park, CA, United States

DSC MRI allows for the characterization of first-pass hemodynamics by measuring signal intensity variation resulting from susceptibility changes during the injection of a paramagnetic contrast agent. Simultaneous spin and gradient-echo (SAGE) DSC MRI sequences can provide perfusion parameters that are sensitive to both microvasculature and larger vessels facilitating the measurement of vessel size and correcting for T1 leakage effects. This work evaluates the integration of SAGE EPI with a simultaneous multi-slice excitation to attain high temporal resolution DSC perfusion with full brain coverage. Two protocols with different multi-band acceleration factors were compared in patients with glioma.

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