Abstract #2975

Simultaneous Multi-Slice Spin and Gradient Echo Dynamic Susceptibility-Contrast Perfusion Imaging of Gliomas

Misung Han¹, Baolian Yang², Brice Fernandez³, Marisa Lafontaine¹, Brian Burns⁴, Suchandrima Banerjee⁴, and Janine M Lupo¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Applications and Workflow, GE Healthcare, Waukesha, WI, United States, ³Applications and Workflow, GE Healthcare, Orsay, France, ⁴Applications and Workflow, GE Healthcare, Menlo Park, CA, United States

DSC MRI allows for the characterization of first-pass hemodynamics by measuring signal intensity variation resulting from susceptibility changes during the injection of a paramagnetic contrast agent. Simultaneous spin and gradient-echo (SAGE) DSC MRI sequences can provide perfusion parameters that are sensitive to both microvasculature and larger vessels facilitating the measurement of vessel size and correcting for T₁ leakage effects. This work evaluates the integration of SAGE EPI with a simultaneous multi-slice excitation to attain high temporal resolution DSC perfusion with full brain coverage. Two protocols with different multi-band acceleration factors were compared in patients with glioma.

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