Abstract #2978

Towards 1 min brain morphometry - evaluating compressed-sensing MPRAGE

Ross W. Mair^1,2, Lindsay C. Hanford^1,3, Emilie Mussard^4,5,6, Tom Hilbert^4,5,6, Tobias Kober^4,5,6, and Randy L. Buckner^1,2,3

¹Center for Brain Science, Harvard University, Cambridge, MA, United States, ²Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Psychology, Harvard University, Cambridge, MA, United States, ⁴Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland, ⁵Department of Radiology, University Hospital, Lausanne, Switzerland, ⁶École Polytechnique, Fédérale de Lausanne, Lausanne, Switzerland

A new MR scan acceleration method, employing incoherent undersampling and compressed-sensing reconstructions, can reduce the scan time for a 1.0 mm MPRAGE to 60-90 seconds, depending on acceleration level. We have validated the morphometrics from a prototype compressed-sensing MPRAGE sequence, with different levels of acceleration, with those from conventional MPRAGE scans. Surfaces created from the compressed-sensing MPRAGE images match those from the conventional scan well. Bulk morphometric values such as total gray and white matter volume, and average cortical thickness are similar to those determined with a conventional MPRAGE scan.

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