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Abstract #2978

Towards 1 min brain morphometry - evaluating compressed-sensing MPRAGE

Ross W. Mair1,2, Lindsay C. Hanford1,3, Emilie Mussard4,5,6, Tom Hilbert4,5,6, Tobias Kober4,5,6, and Randy L. Buckner1,2,3

1Center for Brain Science, Harvard University, Cambridge, MA, United States, 2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Psychology, Harvard University, Cambridge, MA, United States, 4Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland, 5Department of Radiology, University Hospital, Lausanne, Switzerland, 6École Polytechnique, Fédérale de Lausanne, Lausanne, Switzerland

A new MR scan acceleration method, employing incoherent undersampling and compressed-sensing reconstructions, can reduce the scan time for a 1.0 mm MPRAGE to 60-90 seconds, depending on acceleration level. We have validated the morphometrics from a prototype compressed-sensing MPRAGE sequence, with different levels of acceleration, with those from conventional MPRAGE scans. Surfaces created from the compressed-sensing MPRAGE images match those from the conventional scan well. Bulk morphometric values such as total gray and white matter volume, and average cortical thickness are similar to those determined with a conventional MPRAGE scan.

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