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Abstract #2988

Efficient Quantitative MT (qMT) imaging using 3D Segmented EPI readout Variable Flip angle Magnetization Transfer (EP-vfMT) methods

Se-Hong Oh1,2, Ken Sakaie2, and Mark J. Lowe2

1Department of Biomedical Engineering, Hankuk University of Foreign Studies, Yong-in, Korea, Republic of, 2Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States

In this study, newly proposed combined consecutive qMT acquisition scheme was compared with individual MT scan method. Proposed method provides a similar but slightly improved qMT map with slightly higher MT saturation in a clinically feasible scan time. The effect of varying NEX on signal variation of F-map was also investigated. These results suggest that NEX with 2 or 3 is appropriate for the patient scan when considering acquisition time. The EP-vfMT F-map shows high reproducibility (averaged voxel-wise correlation was 0.94 ± 0.03, n=5). These features make the proposed method appealing for clinical neuroimaging applications.

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