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Abstract #2993

Improved quantitative accuracy using ultrahigh resolution DTI-guided QSM

Lijia Zhang1,2, Chris Petty1, and Allen Song1

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Medical Physics, Duke University, Durham, NC, United States

Quantitative susceptibility mapping (QSM) has been increasingly used to help access the brain development, especially white matter myelination. However, the quantitative accuracy is limited by its angle dependence to the magnetic field. In this study, ultrahigh resolution diffusion tensor imaging (DTI) was used to delineate the fiber bundles (i.e. corpus callosal fibers), followed by tract-based QSM to minimize the angle dependence and accurately assess magnetic susceptibility changes in different brain regions.

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