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Abstract #2998

High impact sports and microstructural changes in cortical brain tissue: a 4-year longitudinal study of collegiate athletes

Brian D Mills1, Maged Goubran1, Christian Thaler1, Sherveen Parivash1, Paymon Rezaii1, Wei Bian1, Phillip DiGiacomo1, Lex Mitchell1, Brian Boldt1, Jarrett Rosenberg1, David Douglas1, Jitsupa Wongsripuemtet 1, Huy Do1, Jens Fiehler2, Chiara Giordano1, Max Wintermark1, Gerald Grant1, David Camarillo1, and Michael Zeineh1

1Stanford, Stanford, CA, United States, 2University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Exposure to repeated high-velocity impacts may contribute to increased risk of cognitive impairment. However, there has been limited long-term longitudinal investigations into brain tissue change in high-impact sports. In this large 4-year longitudinal DTI study, high (football) and low-contact (volleyball) athletes show a temporal double dissociation in cortical microstructure: in both the frontal and temporal lobes, cortical FA increases over time in volleyball compared to football. While an increase in ICVF underlies this FA increase in frontal cortex, a decrease in ODI underlies this FA increase in temporal cortex. Exposure to high-impact sports may alter cortical microstructural development.

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