Abstract #2998

High impact sports and microstructural changes in cortical brain tissue: a 4-year longitudinal study of collegiate athletes

Brian D Mills¹, Maged Goubran¹, Christian Thaler¹, Sherveen Parivash¹, Paymon Rezaii¹, Wei Bian¹, Phillip DiGiacomo¹, Lex Mitchell¹, Brian Boldt¹, Jarrett Rosenberg¹, David Douglas¹, Jitsupa Wongsripuemtet ¹, Huy Do¹, Jens Fiehler², Chiara Giordano¹, Max Wintermark¹, Gerald Grant¹, David Camarillo¹, and Michael Zeineh¹

¹Stanford, Stanford, CA, United States, ²University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Exposure to repeated high-velocity impacts may contribute to increased risk of cognitive impairment. However, there has been limited long-term longitudinal investigations into brain tissue change in high-impact sports. In this large 4-year longitudinal DTI study, high (football) and low-contact (volleyball) athletes show a temporal double dissociation in cortical microstructure: in both the frontal and temporal lobes, cortical FA increases over time in volleyball compared to football. While an increase in ICVF underlies this FA increase in frontal cortex, a decrease in ODI underlies this FA increase in temporal cortex. Exposure to high-impact sports may alter cortical microstructural development.

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