Abstract #3009

Altered Functional Connectivity during N-Back Task is Associated with Cognitive Deficits in Mild Traumatic Brain Injury

Nai-Chi Chen^1,2, Chia-Feng Lu^1,3, Li-Chun Hsieh^1,2,4, Sho-Jen Cheng^1,4, Yu-Chieh Jill Kao^1,2, and Cheng-Yu Chen^1,2,4

¹Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

A subgroup of patients with mild traumatic brain injury (mTBI) suffers from a series of cognitive symptoms, including the memory loss and attention deficit. In our study, we investigated the alterations of functional connectivity during N-back working memory task in 46 mTBI and 43 HC using independent component analysis. Despite both groups revealed comparable performances during task, mTBI showed lower functional connectivity in several task-related neural networks that can be correlated with the cognitive complaints. We concluded that the alterations of neural networks may indicate cognitive symptoms after mTBI.

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