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Abstract #3009

Altered Functional Connectivity during N-Back Task is Associated with Cognitive Deficits in Mild Traumatic Brain Injury

Nai-Chi Chen1,2, Chia-Feng Lu1,3, Li-Chun Hsieh1,2,4, Sho-Jen Cheng1,4, Yu-Chieh Jill Kao1,2, and Cheng-Yu Chen1,2,4

1Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 4Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

A subgroup of patients with mild traumatic brain injury (mTBI) suffers from a series of cognitive symptoms, including the memory loss and attention deficit. In our study, we investigated the alterations of functional connectivity during N-back working memory task in 46 mTBI and 43 HC using independent component analysis. Despite both groups revealed comparable performances during task, mTBI showed lower functional connectivity in several task-related neural networks that can be correlated with the cognitive complaints. We concluded that the alterations of neural networks may indicate cognitive symptoms after mTBI.

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