Abstract #3026

Alterations of brain white matter in infants with begin enlargement of subarachnoid space by assessing conventional diffusion and WMTI metrics.

Congcong Liu¹, Miaomiao Wang¹, Xianjun Li¹, Chao Jin¹, Yannan Cheng¹, Huifang Zhao¹, Xingxing Tao¹, Xiaoyu Wang¹, Fan Wu¹, Yuli Zhang¹, and Jian Yang¹

¹Department of Radiology, Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

BESS is characterized by increased cerebrospinal fluid in subarachnoid spaces; some infants with BESS were accompanied with mildly motor and language delay. White matter (WM) development is important to neurodevelopmental outcomes, but relationships between BESS and WM maturation are not very clear. This study aims to quantitative assess WM microstructures of in infant with BESS aged 4-6 months by conventional diffusion and WMTI metrics. Significant decreased FA, α and increased RD, AD, MD, RDe were found in infants with BESS. All results suggested underlying alterations of WM, especially for myelination outside axons. It may provide additional information for neurodevelopment outcomes.

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