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Abstract #3026

Alterations of brain white matter in infants with begin enlargement of subarachnoid space by assessing conventional diffusion and WMTI metrics.

Congcong Liu1, Miaomiao Wang1, Xianjun Li1, Chao Jin1, Yannan Cheng1, Huifang Zhao1, Xingxing Tao1, Xiaoyu Wang1, Fan Wu1, Yuli Zhang1, and Jian Yang1

1Department of Radiology, Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

BESS is characterized by increased cerebrospinal fluid in subarachnoid spaces; some infants with BESS were accompanied with mildly motor and language delay. White matter (WM) development is important to neurodevelopmental outcomes, but relationships between BESS and WM maturation are not very clear. This study aims to quantitative assess WM microstructures of in infant with BESS aged 4-6 months by conventional diffusion and WMTI metrics. Significant decreased FA, α and increased RD, AD, MD, RDe were found in infants with BESS. All results suggested underlying alterations of WM, especially for myelination outside axons. It may provide additional information for neurodevelopment outcomes.

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