Abstract #3033

Atlas-based analysis of brain development from newborn to adolescence using NODDI

Xueying Zhao¹, Jingjing Shi², Fei Dai¹, Wenzhen Zhu², and He Wang¹

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Neurite orientation dispersion and density imaging (NODDI) is a specific designed diffusion model for brain, which provides insights into intra-cellular water contents. Here, we investigated the brain development from 0 to 14 years old using NODDI. The whole brain was divided into 159 regions including cortical gray matter, deep gray matter (dGM) and white matter, and was analyzed through exponential regression. Neurite density presented a higher sensitivity to age-related changes than FA, especially in gray matters. Regional specific asymmetry was found between hemispheres in dGM. Sex difference was observed in the developmental rate of GM.

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