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Abstract #3039

Cerebellar anatomical alterations in youth with complex congenital heart disorder

Athena Buckthought1,2, Gabriel A. Devenyi3,4, Guillaume Gilbert5, Christine Saint-Martin6, Kimberly Fontes1,2, Kaitlyn Easson1,2, Mallar Chakravarty3,4,7, and Marie Brossard-Racine1,2,8

1School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada, 2Advances in Brain and Child Development Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Department of Psychiatry, McGill University, Montreal, QC, Canada, 4Cerebral Imaging Center, Douglas Mental Health University Institute, Verdun, QC, Canada, 5MR Clinical Science, Philips Healthcare, Markham, ON, Canada, 6Department of Radiology, Montreal Children's Hospital, McGill University, Montreal, QC, Canada, 7Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, 8Department of Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada

Individuals with congenital heart defects (CHD) are vulnerable to long-lasting neurodevelopmental impairments. In this study, we found that youth with CHD had overall smaller total and regional volumes in the cerebellum, when compared to healthy controls of the same age. These differences were statistically significant in 18 of 26 bilateral cerebellar regions, but were not significant in lobules I, II, VI and IX as well as Crus I (bilaterally). These anatomical alterations in many regions could lead to functional impairments since the cerebellum plays a role in many aspects of behavior, including movement, cognition and emotional regulation.

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