Abstract #3039

Cerebellar anatomical alterations in youth with complex congenital heart disorder

Athena Buckthought^1,2, Gabriel A. Devenyi^3,4, Guillaume Gilbert⁵, Christine Saint-Martin⁶, Kimberly Fontes^1,2, Kaitlyn Easson^1,2, Mallar Chakravarty^3,4,7, and Marie Brossard-Racine^1,2,8

¹School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada, ²Advances in Brain and Child Development Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Cerebral Imaging Center, Douglas Mental Health University Institute, Verdun, QC, Canada, ⁵MR Clinical Science, Philips Healthcare, Markham, ON, Canada, ⁶Department of Radiology, Montreal Children's Hospital, McGill University, Montreal, QC, Canada, ⁷Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, ⁸Department of Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada

Individuals with congenital heart defects (CHD) are vulnerable to long-lasting neurodevelopmental impairments. In this study, we found that youth with CHD had overall smaller total and regional volumes in the cerebellum, when compared to healthy controls of the same age. These differences were statistically significant in 18 of 26 bilateral cerebellar regions, but were not significant in lobules I, II, VI and IX as well as Crus I (bilaterally). These anatomical alterations in many regions could lead to functional impairments since the cerebellum plays a role in many aspects of behavior, including movement, cognition and emotional regulation.

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