Meeting Banner
Abstract #3041

MRI study of cortical thickness and regional brain volume in pediatric cancer survivors

Patricia Stefancin1, Christine Cahaney1, Robert Parker2, Thomas Preston1, Jessica Goldstein1, Rina Meyer2, Cara Giannillo1, Debra Giugliano1, Tim Duong1, and Laura Hogan2

1Stony Brook Medicine, Stony Brook, NY, United States, 2Stony Brook Children's Hospital, Stony Brook, NY, United States

The concept of pediatric chemobrain and the neural mechanisms that underlie its development have not been adequately studied. In this study, MRI was used to examine the neuroanatomy of childhood cancer survivors. We found reduced brain volumes and cortical thicknesses in childhood cancer survivors compared to age-matched controls. These changes were in regions known to be involved in working-memory function and executive function, which could account for the development of executive function difficulties observed in childhood cancer survivors. These findings may prove useful to inform treatment strategies and modify behavioral programs to help survivors combat these issues.

This abstract and the presentation materials are available to members only; a login is required.

Join Here