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Abstract #3044

Longitudinal characterization of white matter degeneration in a rat model of brain glucose hypometabolism and sporadic Alzheimer's disease

Catarina Tristão Pereira1, Ting Yin2, Yujian Diao2, Analina Raquel da Silva2, and Ileana Ozana Jelescu2

1Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal, 2Centre d'Imagerie Biomédicale, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Animal models can help characterize each contributor to the cascade independently. Here we use the intracerebroventricular-streptozotocin rat model of AD in a first-time longitudinal study of white matter degeneration using diffusion MRI. Diffusion and kurtosis tensor metrics reveal alterations in the cingulum, fimbria and fornix. The two-compartment WMTI-Watson biophysical model further characterizes the cingulum damage as axonal injury and loss - consistent with previous histopathological studies. White matter degeneration induced by brain glucose metabolism disruption can bring further insight into the role of this mechanism in AD.

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