Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Animal models can help characterize each contributor to the cascade independently. Here we use the intracerebroventricular-streptozotocin rat model of AD in a first-time longitudinal study of white matter degeneration using diffusion MRI. Diffusion and kurtosis tensor metrics reveal alterations in the cingulum, fimbria and fornix. The two-compartment WMTI-Watson biophysical model further characterizes the cingulum damage as axonal injury and loss - consistent with previous histopathological studies. White matter degeneration induced by brain glucose metabolism disruption can bring further insight into the role of this mechanism in AD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords