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Abstract #3069

Grading of glioma using a machine learning framework based on optimized features obtained from T1 perfusion MRI and volumes of tumor components

Anirban Sengupta1, Sumeet Agarwal2, Rakesh Kumar Gupta3, Dinil Sasi4, Ayan Debnath4,5, and Anup Singh4

1Centre for Biomedical Engineering, IIT Delhi, New Delhi, India, 2Electrical Engineering, IIT Delhi, Hauz Khas, New Delhi, India, 3Fortis Memorial Research Institute, New Delhi, India, 4IIT Delhi, New Delhi, India, 5University of Pennysylvania, Philadelphia, PA, United States

Grading of glioma based on T1 perfusion MRI parameters is well reported but it has certain challenges specially in differentiating intermediate glioma grades (Grade II vs. III and Grade III vs. IV). In this study, we have differentiated intermediate as well as multiclass glioma grades (Grade II vs. III vs. IV) using an optimized machine learning framework which uses quantitative T1 perfusion MRI parameters in combination with volume of different components of tumor as a feature set. The results show that it is feasible to obtain low error in glioma grading using the proposed methodology. The results also emphasizes the utility of using volume of tumor subparts in conjunction with T1 perfusion MRI parameters for glioma grading.

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