Abstract #3090

Radiomic Features of the Nigrosome-1 Region of the Substantia Nigra: Using Quantitative Susceptibility Mapping to Assist in the Diagnosis of Idiopathic Parkinson’s Disease

Zenghui Cheng¹, Jiping Zhang², Naying He¹, Fuhua Yan¹, E. Mark Haacke³, and Dahong Qian²

¹Ruijin Hospital,school of medicine, Shanghai Jiaotong University, Shanghai, China, ²School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China, ³Radiology, Wayne State University, Detroit, MI, United States

There has been a major effort to study iron deposition in the substantia nigra (SN) because of its relationship to depigmentation of iron in the nigrosome-1 area. Recently, the swallow tail sign (STS) has been introduced as a new biomarker for idiopathic Parkinson’s disease (IPD). In this work, we analyzed the STS region of the SN based on quantitative susceptibility mapping (QSM) via a support vector machine (SVM) classifier and found that this radiomic approach could help to differentiate IPD patients from healthy controls.

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