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Abstract #3090

Radiomic Features of the Nigrosome-1 Region of the Substantia Nigra: Using Quantitative Susceptibility Mapping to Assist in the Diagnosis of Idiopathic Parkinson’s Disease

Zenghui Cheng1, Jiping Zhang2, Naying He1, Fuhua Yan1, E. Mark Haacke3, and Dahong Qian2

1Ruijin Hospital,school of medicine, Shanghai Jiaotong University, Shanghai, China, 2School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China, 3Radiology, Wayne State University, Detroit, MI, United States

There has been a major effort to study iron deposition in the substantia nigra (SN) because of its relationship to depigmentation of iron in the nigrosome-1 area. Recently, the swallow tail sign (STS) has been introduced as a new biomarker for idiopathic Parkinson’s disease (IPD). In this work, we analyzed the STS region of the SN based on quantitative susceptibility mapping (QSM) via a support vector machine (SVM) classifier and found that this radiomic approach could help to differentiate IPD patients from healthy controls.

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