Abstract #3092

Prospective Evaluation of Wave-CAIPI Susceptibility-Weighted Imaging (SWI) Compared to Conventional 3D SWI in a Clinical Setting

John Conklin¹, Maria Gabriela Longo¹, Stephen Cauley², Kawin Setsompop², John Kirsch ¹, Wei Liu³, Sinyeob Ahn⁴, Thomas Beck⁵, Ramon Gonzalez¹, Pamela Schaefer¹, Otto Rapalino¹, and Susie Huang^1,2

¹Radiology, Massachusetts General Hospital (MGH), Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, Charlestown, MA, United States, ³Siemens Healthineers, Shenzhen, China, ⁴Siemens Medical Solutions, San Francisco, CA, United States, ⁵Siemens Healthineers, Erlangen, Germany

We present the first large-scale evaluation of Wave-CAIPI susceptibility-weighted imaging (Wave-SWI) for clinical brain imaging. Wave-SWI was compared to conventional SWI in 107 patients undergoing 3T MRI for a range of indications in both inpatient and outpatient settings. Two neuroradiologists assessed the images in individual and head-to-head comparisons, and found no significant difference between the two sequences for detection of microhemorrhages, visualization of pathology and normal anatomy, and overall diagnostic quality, despite a nearly 5-fold decrease in acquisition time using Wave-SWI. Broader application of highly-accelerated 3D imaging may improve utilization of MRI resources while reducing motion artifacts and patient anxiety.

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