Abstract #3112

Towards a harmonized protocol for structural MRI imaging of the brain for multisite studies in the Italian IRCCS advanced neuroimaging network

Paolo Bosco¹, Laura Biagi¹, Alessandra Retico², Anna Nigri³, Domenico Aquino³, Fulvia Palesi⁴, Maria Grazia Bruzzone³, Claudia A.M. Gandini Wheeler-Kingshott^5,6,7, Michela Tosetti¹, and The Italian IRCCS advanced neuroimaging network⁸

¹IRCCS Fondazione Stella Maris, Pisa, Italy, ²INFN, Pisa Division, Pisa, Italy, ³Fondazione IRCCS Istituto neurologico “Carlo Besta”, Milan, Italy, ⁴Radiology Department, IRCCS Fondazione Mondino, Pavia, Italy, ⁵Brain MRI 3T Research Center, IRCCS Fondazione Mondino, Pavia, Italy, ⁶Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁷Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ⁸The Italian IRCCS advanced neuroimaging network, Milan, Italy

MRI derived brain structural measurements from multicenter datasets can strongly be affected by factors such as the acquisition protocol, the static magnetic field strength and the scanner manufacturer. A preliminary study was performed to assess the homogeneity of population metrics from 3DT1 scans acquired with already established routine protocols in a dataset of 174 healthy subjects from 18 Italian Research Hospital Centers (IRCCS). The impact of each center acquisition parameters on outcomes was assessed with quality control measurements and FreeSurfer volumetric metrics of cortical and subcortical structures. Future multicenter studies will benefit from harmonizing the acquisition protocols.

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