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Abstract #3112

Towards a harmonized protocol for structural MRI imaging of the brain for multisite studies in the Italian IRCCS advanced neuroimaging network

Paolo Bosco1, Laura Biagi1, Alessandra Retico2, Anna Nigri3, Domenico Aquino3, Fulvia Palesi4, Maria Grazia Bruzzone3, Claudia A.M. Gandini Wheeler-Kingshott5,6,7, Michela Tosetti1, and The Italian IRCCS advanced neuroimaging network8

1IRCCS Fondazione Stella Maris, Pisa, Italy, 2INFN, Pisa Division, Pisa, Italy, 3Fondazione IRCCS Istituto neurologico “Carlo Besta”, Milan, Italy, 4Radiology Department, IRCCS Fondazione Mondino, Pavia, Italy, 5Brain MRI 3T Research Center, IRCCS Fondazione Mondino, Pavia, Italy, 6Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 7Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 8The Italian IRCCS advanced neuroimaging network, Milan, Italy

MRI derived brain structural measurements from multicenter datasets can strongly be affected by factors such as the acquisition protocol, the static magnetic field strength and the scanner manufacturer. A preliminary study was performed to assess the homogeneity of population metrics from 3DT1 scans acquired with already established routine protocols in a dataset of 174 healthy subjects from 18 Italian Research Hospital Centers (IRCCS). The impact of each center acquisition parameters on outcomes was assessed with quality control measurements and FreeSurfer volumetric metrics of cortical and subcortical structures. Future multicenter studies will benefit from harmonizing the acquisition protocols.

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