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Abstract #3117

Corpus callosum involvement in mesial temporal lobe epilepsy and non lesional frontal lobe epilepsy: a multimodal MRI study

Maria Eugenia Caligiuri1,2, Angelo Labate3, Aldo Quattrone1,2, and Antonio Gambardella3

1Neuroscience Research Center, University Magna Graecia of Catanzaro, Catanzaro, Italy, 2Neuroimaging Unit, Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Catanzaro, Italy, 3Institute of Neurology, University Magna Graecia of Catanzaro, Catanzaro, Italy

Mesial Temporal Lobe Epilepsy (MTLE) and Frontal Lobe Epilepsy (FLE) are the two most common forms of partial epilepsy. While MTLE has been widely studied, FLE has been less investigated. Patients with FLE in which there is no clearly identifiable abnormality on MRI (non lesional FLE, nlFLE) represent an ideal sample to study the epileptic syndrome itself, regardless of the nature and location of the epileptogenic focus in the frontal lobe. Here, we studied the involvement of the corpus callosum in temporal and frontal lobe epilepsy, considering non-lesional FLE, refractory MTLE and mild MTLE, a particularly drug-responsive phenotype. Neuroimaging characteristics of CC seem to be indeed altered with patterns that are specific to the different epileptic syndromes.

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