Mesial Temporal Lobe Epilepsy (MTLE) and Frontal Lobe Epilepsy (FLE) are the two most common forms of partial epilepsy. While MTLE has been widely studied, FLE has been less investigated. Patients with FLE in which there is no clearly identifiable abnormality on MRI (non lesional FLE, nlFLE) represent an ideal sample to study the epileptic syndrome itself, regardless of the nature and location of the epileptogenic focus in the frontal lobe. Here, we studied the involvement of the corpus callosum in temporal and frontal lobe epilepsy, considering non-lesional FLE, refractory MTLE and mild MTLE, a particularly drug-responsive phenotype. Neuroimaging characteristics of CC seem to be indeed altered with patterns that are specific to the different epileptic syndromes.