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Abstract #3143

Grey matter atrophy measured with MRI correlates with reduced neuronal density in the experimental autoimmune encephalomyelitis model of multiple sclerosis

A. Max Hamilton1,2,3,4, Nils D. Forkert1,2, Ying Wu1,2,3,4, James A. Rogers2,3, V. Wee Yong2,3, and Jeff F. Dunn1,2,3,4

1Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, 4Experimental Imaging Center, University of Calgary, Calgary, AB, Canada

Atrophy is a clinical marker of neurodegeneration and progressive disability in multiple sclerosis (MS). To test neuroprotective treatments aimed at reducing atrophy, mouse models featuring atrophy are needed. We have shown the experimental autoimmune encephalomyelitis (EAE) mouse model features atrophy, though we do not know if EAE atrophy is caused by neurodegeneration, as it is in MS. We used MRI and atlas-based regional volumetrics to measure atrophy in EAE, while using immunohistochemistry to measure neurodegeneration. Atrophy measured in the cerebellum and cerebral cortex correlated with neuronal loss, suggesting we can use EAE along with MRI to test neuroprotective therapies.

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