Abstract #3149

Action observation training increases dynamic functional connectivity in patients with multiple sclerosis

Maria A. Rocca^1,2, Loredana Storelli¹, Claudio Cordani¹, Paola Valsasina¹, Luca Gavazzeni¹, Alessandro Meani¹, Paolo Preziosa^1,2, Federica Esposito², and Massimo Filippi^1,2

¹Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Action Observation Training (AOT) seems to be a promising tool to improve upper limb function. We applied a novel method of analysis, which allows a time-varying (dynamic) assessment of resting state functional connectivity on two randomized experimental groups of healthy controls and multiple sclerosis (MS) patients and two control groups. Between-group differences and dynamic functional network connectivity (dFNC) changes over-time in each group were evaluated. After a training of 2 weeks, MS groups improved in right upper limb functions and AOT showed a modulation of dFNC of several functional networks in MS patients.

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