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Abstract #3149

Action observation training increases dynamic functional connectivity in patients with multiple sclerosis

Maria A. Rocca1,2, Loredana Storelli1, Claudio Cordani1, Paola Valsasina1, Luca Gavazzeni1, Alessandro Meani1, Paolo Preziosa1,2, Federica Esposito2, and Massimo Filippi1,2

1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Action Observation Training (AOT) seems to be a promising tool to improve upper limb function. We applied a novel method of analysis, which allows a time-varying (dynamic) assessment of resting state functional connectivity on two randomized experimental groups of healthy controls and multiple sclerosis (MS) patients and two control groups. Between-group differences and dynamic functional network connectivity (dFNC) changes over-time in each group were evaluated. After a training of 2 weeks, MS groups improved in right upper limb functions and AOT showed a modulation of dFNC of several functional networks in MS patients.

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